Safety and Efficacy of Platelet-rich Plasma Injection for Treatment of Erectile Dysfunction: A Prospective Randomized Controlled Study

Abstract Background Affected sexual relationships have an effect on both men's and women's quality of life (QoL). Because of their ability to aid in tissue healing and vascular remodeling, platelet-derived therapies are becoming more and more popular in a variety of medical and surgical fields. The purpose of this research is to assess the safety and effectiveness of treating patients having erectile dysfunction (ED) with platelet-rich plasma (PRP) injections. Patients and Methods: A prospective, double-blinded, randomized, placebo-controlled study had been conducted to evaluate patients suffering from ED in Urology outpatient clinics at Beni-Suef University Hospital in Egypt. 52 participants with mild to moderate ED were divided into two groups: group A, who received three PRP penile injections, and group B, who received three saline injections, 9 ml for each injection site. Results A month after the last injection, the PRP group's IIEF was 16.12 ± 1.25, while the placebo group's was 15.99 ± 1.21 (p = 0.683). Following a 3-month period, the IIEF for the PRP group was 16.44 ± 1.17, while the placebo group's was 16.31 ± 1.06 (p value = 0.653). Following a 6-month period, the IIEF for the PRP group was 16.35 ± 1.45, while the placebo group's was 16.23 ± 1.19 (p value = 0.727). In terms of IIEF, there was no significant difference between the two groups following one, three, and six months of treatment. Conclusion In brief, our research revealed no data to support the application of PRP injections in the management of mild to moderate ED.