March 1, 2024

Targeting the DHX9 RNA Helicase to Induce Antitumor Immunity in Small-Cell Lung Cancer

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Resumen

Summary: Murayama and colleagues establish DHX9 as an exciting new target to induce viral mimicry and downstream antitumor immunity. The potential for use in combination with existing immune therapies is especially exciting in SCLC, an immunologically cold and deadly disease. See related article by Murayama et al., p. 468 (10) .

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Katherine B. Chiappinelli (Fri,) studied this question.

synapsesocial.com/papers/68e76495b6db6435876da20d https://doi.org/https://doi.org/10.1158/2159-8290.cd-23-1523

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1Small-cell lung cancer2021 · 1,531 citations
2DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts2015 · 1,525 citations
3R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response2022 · 300 citations
4Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses2015 · 2,001 citations
5Targeting DHX9 Triggers Tumor-Intrinsic Interferon Response and Replication Stress in Small Cell Lung Cancer2024 · 100 citations

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