1064 Demographic profile and management of ovarian cancers; lethal but commonly misunderstood disease: a tertiary care centre experience

Introduction/Background As per Globocan 2020 data, Ovarian malignancies are the third most common cause of cancer and cancer related deaths in India females. It poses unique challenges to doctors in our country due to myriad histologically, advanced stage at presentation, non compliance of the patients, high mortality and lack of effective screening practices. The management of ovarian malignancies requires a multimodality approach comprising of initial surgery for staging or optimal cytoreduction followed by chemotherapy and in some cases an interval or secondary cytoreductive surgery. Recent trials have established the role of HIPEC in selected cases. Management also needs to be individualised based on the histopathology. Hence, this study was undertaken to understand the clinicopathological and demographic profile of ovarian cancers, their spectrum of presentations and management. Methodology In this retrospective study, 50 patients were included who presented with ovarian lesions in the Department of Surgical Oncology, ESIPGIMSR, Basaidarapur, New Delhi from January 2021 to December 2021 and were followed up for further 1 year. Results Peak incidence was observed in 6th decade. Family history was positive in 14% patients. 20% patients were BRCA positive. The most common stage at presentation was FIGO Stage III (40%) while 18% patients presented with metastatic disease. Predominant histology was serous carcinoma (20%). 9 out of 50 patients developed recurrence after undergoing surgery and/or receiving chemotherapy. Conclusion Ovarian cancers continue to be one of the most common and lethal cancers amongst Indian females. Effective screening, early diagnosis and vigilant follow up are crucial for reducing mortality rates and improving survival outcomes. Disclosures None.