P93 Investigation of clinical and laboratory characteristics and survival of SLE patients with and without lupus nephritis

Objective Lupus nephritis (LN) is one of the most severe organ manifestations in SLE. The aim of our study was to determine the incidence of LN and to compare the clinical characteristics, survival rate and outcome of SLE patients with and without LN. We also compared the data of patients diagnosed with LN before and after 2005. Methods The patients were followed up between 1990 and 2020 at the Dept. of Clinical Immunology, Faculty of Medicine, University of Debrecen. We recorded the clinical and laboratory findings of the patients, as well as their immunosuppressive treatments. Results Of 384 SLE patients, 127 had LN (33.07%). The age at the onset of SLE was significantly lower in patients with LN (pConclusion Lupus nephritis did not influence disease outcome in our SLE patients. Low disease activity status significantly improves survival in LN but not in SLE patients without LN. The main therapeutic goal is to achieve remission in SLE patients with or without LN.