32P Clinical profile and presentation of patients with gastroenteropancreatic neuroendocrine neoplasms: An updated dataset from India

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are uncommon cancers globally. The data on their clinical presentation, site of tumour and its grading, from India is scarce. We retrospectively collected anonymised patient data from our electronic health records from 1st May 2011 to 1st Oct 2023. The information was initially collected in an excel sheet and then analysed for various parameters. We saw 418 patients with Neuroendocrine Neoplasms in our data set. Out of those, more than 81% (n=339) were GEP-NENs with male preponderance (Females=138). The median age of presentation for GEP-NENs was 60 years (Range: 12-90). Most common primary site of tumour was small intestine (37%, n=123) with maximum incidence in Pancreas (n=80) followed by Duodenum (n=72). Least common site was Esophagus/Gastroesophageal junction (n=5). With respect to tumour grading (WHO), we found G1 (125) G2 as most common (n=83) and G3 the least (n=50), information for 39% of tumours was not available, mostly because of inadequate tissue sample or incomplete review due to lack of follow up by the patients. Only 10 patients (3%) presented with carcinoid syndrome and most common symptom was diarrhoea (n=9). DOTA PET scan was done in about 44% (n=143) patients as initial imaging tool for staging. Half of the patients with GEP-NENs presented to our clinic with metastasis to various sites with liver being most common organ. About 19% patients had upfront Echocardiography to see for any carcinoid heart but only 1 patient was found to have hypertrophy of the right ventricle. GEP-NENs are most common NENs observed. Small intestine is the most common site for GEP-NENs and it matches with the published global data. Carcinoid syndrome can be the presenting complaint, but we had less incidence.