110P The relationship between tumor necrosis, histopathology type, and preoperative chemotherapy regimens in patients with osteosarcoma

Our research aimed to investigate the potential correlations between the extent of tumor necrosis and various factors, such as histopathological types, preoperative chemotherapy regimens, and other factors, in high-grade osteosarcoma patients treated at our institution. We retrospectively reviewed 79 patients with stage IIB high-grade osteosarcoma treated in our institution from 2021 to 2023. Patient and treatment factors such as age, gender, tumor site, histological type, tumor size, tumor necrosis rate, chemotherapy regimens and cycles were recorded. Our 79 patients included 52 males and 27 females, ranging in age from 8 to 33 years (median, 15 years). The tumor necrosis rate ranged from 5 to 100% (median 85%). The tumor necrosis rate was greater than 90% in 21 patients, 70–90% in 30 patients, and less than 70% in 22 patients. Tumor necrosis rates were not significantly different when patients were grouped by age, gender, tumor site, tumor size, pathological type, or preoperative chemotherapy regimens. In our study, no correlation was observed between the degree of tumor necrosis and both preoperative treatment regimens and histological types among osteosarcoma patients. Our findings underscore the importance of conducting future research with larger sample sizes to provide a more comprehensive understanding of these intricate relationships within the context of bone cancer pathology.