4CPS-104 Comorbidity patterns in the older HIV patient

Background and Importance The life expectancy of people living with HIV (PLHIV) has risen. However, PLHIV present chronic systemic inflammation, which results in premature ageing and an increased risk of age-associated comorbidities compared to the general population. Aim and Objectives To determine the prevalence of comorbidities among PLHIV who are 65 years old or above, and to categorise their distribution in multimorbidity patterns according to the study by Prado Torres et al: cardio-metabolic, depressive-geriatric and mechanical-thyroid. Material and Methods Prospective descriptive study through interviews with 47 PLHIV over 65 years of age on active antiretroviral treatment seen in the outpatient pharmaceutical care clinic. The comorbidities were obtained from the computerised clinical history (Selene®), the primary care health history (Horus®) and the clinical interview with the patient. The comorbidities were classified into comorbidity patterns according to the study by Prado Torres et al, which is included in the 'Model of Selection and Pharmaceutical Care for HIV Patients' by the Hospital Pharmacy Society of our country. A comorbidity pattern is diagnosed in a patient if they present at least two pathologies of the same pattern. Multiple patterns of comorbidity may be present in a patient. Results The patients had a median of 5 comorbidities (RIQ: 2–6). Out of 47 patients, 28 (60.0%) present a cardio-metabolic pattern, 13 (27.7%) a depressive-geriatric pattern and 18 (38.3%) a mechanical-thyroid pattern. Two patients had up to 7 pathologies of the same pattern. 4 patients (8.5%) had over 10 comorbidities. 57.4% of the patients suffered from arterial hypertension, 53.2% dyslipemia, 31.9% diabetes and 23.4% benign prostatic hypertrophy. Conclusion and Relevance In conclusion, non-HIV-related comorbidities are increasingly important in older HIV-infected people. It is important to detect and prevent modifiable age-related risks of non-HIV comorbidities. It is necessary to develop a multidisciplinary approach to ensure high-quality clinical care in these patients. Understanding the range of comorbidity patterns facilitates precision in developing forthcoming health interventions in complex elderly PLHIV. References and/or Acknowledgements Conflict of Interest No conflict of interest.