Catalyst-free Aloe Vera-promoted Cyclization of 2-Amino-azarenes with Phenacyl Bromide

Introduction: By condensing 2-aminothiazole and phenacyl bromide, a novel catalystfree synthetic approach for the synthesis of imidazo2,1-bthiazole derivatives has been developed. Methods: In this work, aloe vera/water (3:2) is used as a reusable, environmentally benign, greenpromoting media to synthesize desired products. This method enables the synthesis of a diverse range of aryl-substituted imidazo2,1-bthiazoles. Results: This solvent system demonstrates remarkable efficiency and offers numerous advantages, including shorter reaction times, the absence of side product formation, costeffectiveness, excellent atom efficiency, straightforward operation, and high yields. Conclusion: In conclusion, we successfully developed a green protocol for the environmentally benign synthesis of imidazo2,1-bthiazole derivatives using aloe vera water as green-promoting media.