Chronic non-communicable diseases (NCDs) represent the greatest medical challenge of the 21st 2 century. Eighty percent of the etiology of chronic diseases is non-genetic. Chronic diseases are not 3 monogenetic, static defects, but rather the expression of disturbed regulatory processes within the 4 body’s biological memory systems — metabolic, immunological, and neuronal. Regenerative medicine 5 understands health as a dynamic state of functional energy allocation and adaptive plasticity, which 6 can be regulated through epigenetic, mitochondrial, and neuroendocrine mechanisms. It connects 7 modern systems biology with the principles of behavioral and neuropsychology and emphasizes 8 that self-efficacy, coherence, and voluntariness are not ethical ideals but biological necessities for 9 healing. Emerging evidence shows that targeted habitual interventions can induce profound changes 10 in gene expression, mitohormesis, and immune regulation, making epigenetically fixed disease patterns 11 partially reversible. By integrating molecular biology, behavioral science, and mentor-based formats, 12 regenerative medicine bridges the gap between biomedical knowledge and effective patient care. 13 This paper formulates a new paradigm: regeneration is not a passive process but an active learning 14 process of the organism. Healing arises when biological, psychological, and social systems are brought 15 into coherent resonance. In this sense, regenerative medicine forms the bridge between molecular 16 biology, lifestyle research, and human experience — with the goal of not merely measuring health, but 17 consciously cultivating it.
Keferstein et al. (Wed,) studied this question.