December 2, 2025Open Access

A novel interleaved TMS-MRS approach with standard MRI hardware

Puntos clave

Neurochemical changes were detected during stimulation in TRD patients, highlighting a novel interleaved approach.
The study shows the feasibility of using standard MRI hardware for in-vivo detection of neurochemical changes.
Analysis employs interleaved TMS-MRS to explore excitatory/inhibitory balance and neuronal metabolism during treatment.
This new method may enable further understanding of treatment mechanisms in patients with treatment-resistant depression.

Resumen

Interleaved TMS-MRS is feasible with standard MRI hardware in TRD patients, enabling in-vivo detection of acute neurochemical changes during stimulation. This method offers a new avenue for probing excitatory/inhibitory balance, neuronal metabolism, and treatment mechanisms.

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Cite This Study

Vasileiadi et al. (Tue,) studied this question.

synapsesocial.com/papers/6940274a2d562116f28ff58a https://doi.org/https://doi.org/10.1016/j.brs.2025.102997

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