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Donanemab in early symptomatic Alzheimer’s disease: results from the TRAILBLAZER-ALZ 2 long-term extension | Synapse
December 1, 2025
Open Access
Donanemab in early symptomatic Alzheimer’s disease: results from the TRAILBLAZER-ALZ 2 long-term extension
GT
Giulia Tronchin
Cognitive Neuroimaging Lab
SS
Shoichiro Sato
Eli Lilly (United States)
LR
Lars Lau Rakêt
Eli Lilly (United States)
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Puntos clave
Donanemab slows cognitive decline in patients with early symptomatic Alzheimer's disease, potentially aiding treatment strategies.
Long-term extension data from TRAILBLAZER-ALZ 2 shows continued treatment effects over time, emphasizing sustainability of intervention.
Analysis of the trial's extension phase highlights the treatment's efficacy in reducing symptoms in Alzheimer's disease barriers to progress.
Further validation of these findings is warranted to strengthen the case for donanemab as a viable therapy option.
Resumen
ClinicalTrials.gov identifier NCT04437511.
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Tronchin et al. (Mon,) studied this question.
synapsesocial.com/papers/694028d52d562116f2900964
https://doi.org/https://doi.org/10.1016/j.tjpad.2025.100446
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