A Sensitive Method for the Quantitation of the Peptide-Based Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Plasma Using Microfluidics Chromatography Tandem MS

The dynamic range of our LC-MS/MS assay provides sufficient coverage of the average efficacious liraglutide concentrations in human plasma, and can be used for pharmacokinetics/pharmacodynamics studies in animals and potentially in humans.