Patients with high FIB-4 and CA125 levels experienced significantly higher morbidity, including more emergency visits and readmissions, compared to those without high values.
Does combining the FIB-4 and CA125 indices in patients hospitalized for acute heart failure identify subgroups with differing risks of morbidity and mortality?
The combination of elevated FIB-4 and CA125 indices at admission for acute heart failure identifies a subgroup of patients at high risk for short- to medium-term clinical worsening and readmissions.
Tasa de eventos absoluta: 0% vs 0%
Background: The implementation of the fibrosis 4 (FIB-4) index was initially associated with hepatic dysfunction; however, this index may also provide prognostic information in heart failure (HF). Thus, this study aimed to assess whether combining the FIB-4 and carbohydrate antigen 125 (CA125) indices in patients hospitalized for acute heart failure (AHF) can identify subgroups with differing risks of morbidity and mortality. Methods: This retrospective study included 402 patients consecutively admitted for AHF between January 2023 and December 2024, after excluding elective admissions (n = 403), inter-hospital transfers (n = 232), and low-output cases (n = 51). Patients were stratified into four groups according to the FIB-4 score ( 0.1). Conclusions: The FIB-4 index may be a useful indicator in AHF. Elevated values at admission for decompensation, in combination with high CA125 levels, can be used to identify a subgroup of patients with poor short- to medium-term outcomes, particularly in terms of worsening. Further studies are needed to determine the actual utility of the FIB-4 index in the context of AHF.
Appiani et al. (Mon,) reported a other. Patients with high FIB-4 and CA125 levels experienced significantly higher morbidity, including more emergency visits and readmissions, compared to those without high values.
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