Abstract BACKGROUND: Circulating microparticles (MPs) may trigger a hypercoagulable state, leading to thrombosis. Cerebral venous thrombosis (CVT) is a rare but serious thrombotic disease. Yet, the correlation between circulating MPs and CVT remains unclear. Therefore, this study aimed to clarify the relationship between circulating MPs and CVT. MATERIALS AND METHODS: A total of 110 patients newly diagnosed with CVT and 89 healthy controls were enrolled. MPs derived from endothelial cell (CD144+), tissue factor (TF+), monocyte cell (CD14+), and platelet (CD41a+) were isolated from platelet-poor plasma prepared by centrifugation and determined using flow cytometry. To analyze disease severity and prognosis, CVT patients were stratified into subgroups based on their Glasgow Coma Scale score at admission or their Modified Rankin Scale score at the 3-month follow-up. RESULTS: Plasma levels of CD144+, TF+, CD14+, and CD41a+ MPs were significantly higher in CVT patients than in healthy controls (all P < 0.05). Furthermore, the circulating TF+ MP levels showed significant positive correlations with both CVT severity ( r = 0.401, P = 0.003) and prognosis ( r = 0.316, P = 0.012). Logistic regression analysis revealed that higher TF+ MP levels were an independent predictor for severity ( P = 0.005) at admission and poor prognosis ( P = 0.027) at 3 months of CVT. Moreover, the area under the curve was 0.824 and 0.843 in severity and prognosis of CVT, respectively, as shown by the receiver operating characteristic curve. CONCLUSIONS: Compared with healthy controls, circulating MP amounts were higher in CVT patients. The TF+ MP levels may be effectively utilized as a biomarker of CVT severity and clinical prognosis.
He et al. (Mon,) studied this question.