Mice with systemic sclerosis exhibited enhanced MMP activity in the aortic wall, leading to increased susceptibility to aortic dissection.
Mice with systemic sclerosis show increased susceptibility to aortic dissection linked to enhanced MMP activity, highlighting a potential therapeutic target.
Tasa de eventos absoluta: 0% vs 0%
Mice with SSc were more prone to aortic dissection, potentially due to enhanced MMP activity in the aortic wall, underlining the importance of MMPs in the pathogenesis of aortic dissection in connective tissue diseases and indicating a pathway for future therapeutic interventions by targeting MMPs to mitigate the risk of aortic dissection in patients with SSc.
Yang et al. (Tue,) reported a other. Mice with systemic sclerosis exhibited enhanced MMP activity in the aortic wall, leading to increased susceptibility to aortic dissection.