What question did this study set out to answer?

The study aims to report clinical cases of primary hyperparathyroidism that led to severe bone complications.

January 22, 2026Open Access

Three Malagasy Cases of Severe Bone Complications Revealing Primary Hyperparathyroidism

Puntos clave

The study aims to report clinical cases of primary hyperparathyroidism that led to severe bone complications.
Documented three clinical cases of primary hyperparathyroidism in Malagasy individuals.
Analyzed skeletal deformities and fractures resulting from the condition.
Identified the unusual early onset and atypical phenotype in the cases.
All three cases exhibited catastrophic skeletal deformities due to primary hyperparathyroidism.
Pathological fractures were present in each case, indicating severe bone health issues.
The findings underscore the rarity and seriousness of PHPT in individuals under 25.

Resumen

Primary hyperparathyroidism (PHPT) is a metabolic disorder characterized by hypercalcemia with elevated or unsuppressed parathyroid hormone (PTH). It is rare in children but common in adults, particularly in women around the age of 50. In 85% of cases, PHPT is asymptomatic and is diagnosed following hypercalcemia and elevated PTH levels during routine examinations. PHPT occurring before the age of 25 and the normocalcemic phenotype are unusual situations that may delay diagnosis. These nonclassical forms expose patients to severe bone complications that can cause disability. Our objective is to report three clinical cases of PHPT revealed by catastrophic skeletal deformities and pathological fractures.

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