Abstract Background Inflammatory Bowel Diseases (IBD) may have extraintestinal manifestations (EIMs) in up to 50% of patients with IBD and can impact on the quality of life (QoL). No previous studies have explored whether EIMs can affect the quality of life in patients with IBD, therefore, the aim of this study aims was to evaluate the impact of EIMs on QoL in patients with IBD. Methods This is a case-control study that included 243 patients diagnosed with IBD (132 without EIMs and 111 with EIMs). The IBDQ-32 questionnaire was applied to all patients in order to evaluate the quality of life. Negative quality of life was considered as a cut-off value 170 points. Univariate and multivariate analyses were conducted to find associations between altered QoL in IBD patients. The SPSS program version 27 was used for the statistical analysis and P ≤ 0.05 was considered as significant. Results Patients with IBD who had EIMs showed significantly worse quality of life compared to those without EIMs (P = 0.001; OR = 2.29, 95% CI: 1.3-3.8) and this effect was also observed when was adjusted for IBD activity (P = 0.003; OR = 2.24, 95% CI: 1.3-3.8). In the subgroup analysis by dimensions of the IBDQ-32, we found that social function (P 0.0001); systemic symptoms (P 0.0001); intestinal symptoms (P 0.0001); and emotional (P 0.0001) were affected in all patients with EIMs. In the subgroup analysis by type of EIMs, we found that arthralgias (P = 0.004; OR = 2.2, 95% CI: 1.3-4.0) and osteopenia were associated with worse QoL (P = 0.04; OR = 3.0, 95% CI: 1.05-9.0). Conclusion Patients with IBD and EIMs had worse quality of life compared than those without EIMs regardless of IBD activity. The worse QoL was present in all IBDQ-32 domains. Conflict of interest: Prof. Dr. Yamamoto-Furusho, Jesús Kazuo: No conflict of interest Gutierrez-Herrera, Fausto Damian: No conflict of interest
Yamamoto-Furusho et al. (Thu,) studied this question.