What question did this study set out to answer?

This study aims to evaluate how well umbilicocerebral and cerebroplacental ratios can predict adverse outcomes in pregnancies with late-onset fetal growth restriction.

January 25, 2026

Prognostic Value of Umbilicocerebral and Cerebroplacental Ratios inLate-Onset Fetal Growth Restriction: A Prospective Observational Study

Puntos clave

This study aims to evaluate how well umbilicocerebral and cerebroplacental ratios can predict adverse outcomes in pregnancies with late-onset fetal growth restriction.
Conducted as a prospective observational study at a tertiary care facility over 18 months.
Included antenatal women between 32 and 40 weeks diagnosed with late-onset fetal growth restriction.
Calculated cerebroplacental and umbilicocerebral ratios using Doppler ultrasound measurements of fetal arteries.
Followed patients until delivery to analyze perinatal outcomes.
77.3% of women had abnormal cerebroplacental ratios.
41.3% of women had abnormal umbilicocerebral ratios.
Adverse outcomes including NICU admissions, preterm births, and perinatal mortality were significantly more frequent with abnormal CPR and UCR.

Resumen

Introduction/Objectives: Fetal growth restriction (FGR) is a significant obstetric concern due to its association with adverse perinatal outcomes. This study aims to compare the prognostic utility of the umbilicocerebral ratio (UCR) and cerebroplacental ratio (CPR) in predicting adverse outcomes in pregnancies complicated by late-onset FGR. Method: This prospective observational study was conducted over 18 months at a tertiary care center. Antenatal women between 32 and 40 weeks of gestation diagnosed with late-onset FGR were included. Pulsatility indices (PI) of the fetal middle cerebral artery and umbilical artery were obtained via Doppler ultrasound to calculate CPR and UCR. Thresholds used were CPR ≤1.76 and UCR ≥1. Patients were followed until delivery, and perinatal outcomes were analyzed. Results: Of the 75 women enrolled, abnormal CPR was present in 58 (77.3%) and abnormal UCR in 31 (41.3%). Adverse perinatal outcomes were significantly more frequent among those with abnormal CPR and UCR, including NICU admission, preterm birth, and perinatal mortality. Discussion: The present study suggests integrating CPR and UCR together into routine Doppler surveillance of pregnancies with suspected FGR, especially in late gestation. An abnormal CPR should prompt close monitoring and possibly early delivery planning to prevent stillbirths or NICU admissions. Elevated UCR, given its correlation with low Apgar and perinatal death, may serve as an early warning for escalating fetal compromise. Conclusión: CPR and UCR are valuable tools for monitoring pregnancies complicated by lateonset FGR. Used together, they enhance the prediction of adverse perinatal outcomes, allowing timely and targeted clinical interventions.

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