Triple-helix crosslinked Hydrogels with Sol-gel Transition in Response to Collagen Model Peptides

Puntos clave

• The research aims to create a hydrogel that responds to temperature changes and is influenced by collagen model peptides.
• Developed a thermoresponsive hydrogel crosslinked with a collagen-motif triple helix.
• Analyzed sol-gel transition properties based on grafted collagen model peptides (CMPs).
• Investigated the role of amino acid sequence variation and the effect of additional single-strand CMPs.
• The hydrogel showed a controllable sol-gel transition property based on CMP interactions.
• Triple helix formation significantly impacted the hydrogel's properties and responsiveness to temperature changes.