YAP6SA overexpression induces cardiomyocyte cell cycle reentry and is well tolerated in mammalian hearts, providing new insights into cardiac regeneration mechanisms.
YAP6SA promotes cardiomyocyte cell cycle reentry through TEAD-independent mechanisms involving MPDZ and Rho GTPases, providing novel mechanistic insights into mammalian cardiac regeneration.
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Adult mammalian hearts exhibit limited regenerative capacity because of the restricted renewal of cardiomyocytes. Recent studies reveal that mammalian hearts exhibit transient regenerative potential within a short time frame after birth, suggesting a regulatory mechanism that prevents adult hearts from initiating a regenerative response to cardiac injury. Here, we discovered that an active form of YAP, named YAP6SA, which is not inhibited by the Hippo signaling pathway and does not interact with TEADs, induces cardiomyocyte cell cycle reentry. In addition, YAP6SA interacts with scaffold protein MPDZ to regulate Rho GTPases and promote cell cycle progression in cardiomyocytes (CMs). Importantly, YAP6SA overexpression is well tolerated in mammalian hearts. These findings provide new insights into YAP function in cardiomyocytes.
Xie et al. (Wed,) reported a other. YAP6SA overexpression induces cardiomyocyte cell cycle reentry and is well tolerated in mammalian hearts, providing new insights into cardiac regeneration mechanisms.