This study demonstrates the facile removal of benzyl-derived protecting groups via ammonia-free, mechanochemically driven Birch reduction using inexpensive and easy-to-handle sodium lumps. Various benzyl-protected alcohols and amines were efficiently deprotected within 30 min. Notably, all synthetic operations can be performed without inert gases or bulk solvents.
Kondo et al. (Thu,) studied this question.
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