Aortic aneurysms were associated with a 3-fold increased risk of incident dilated cardiomyopathy (HR 3.04; 95% CI 1.50-6.18) and heart failure (HR 3.32; 95% CI 3.13-3.52) compared to matched controls.
Cohort (n=164,021)
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Does the presence of an aortic aneurysm increase the risk of developing dilated cardiomyopathy or heart failure in adults without genetic syndromes?
Patients with aortic aneurysms have an approximately 3-fold increased risk of developing incident dilated cardiomyopathy or heart failure compared to matched controls.
Estimación del efecto: HR 3.04 (95% CI 1.50-6.18)
Tasa de eventos absoluta: 0.14% vs 0.06%
Abstract Background A dilated aorta and dilated cardiomyopathy frequently coexist in some genetic syndromes. Greater aortic root size is also associated with lower left ventricular ejection fraction in the community, but the relation between diagnosed aortic aneurysms and risks of dilated cardiomyopathy and heart failure in people without known genetic syndromes is unknown. Methods Through nationwide Danish health care registries, we included all individuals over 18 years of age with a diagnosis of any aortic aneurysms and 10 age- and sex-matched controls. These were followed between 1994-2018 for incident dilated cardiomyopathy and heart failure. Patients with known genetic syndromes and bicuspid aortic valves were excluded. Cox proportional hazards regression was used to compute hazard ratios for developing dilated cardiomyopathy or heart failure. Results Totally 14,911 individuals with aortic aneurysms (mean age 68.6 years (SD 12.8), 40% female) were included. These had a higher prevalence of dilated cardiomyopathy (0.07% vs 0.03%) and heart failure (8.7% vs 3.8%), compared to controls. Crude incidence rate per 1000 person-years of dilated cardiomyopathy was 0.14 (95%CI 0.07-0.27) vs 0.06 (95%CI 0.05-0.08) in cases vs controls, adjusted hazard ratio 3.04 (95%CI 1.50-6.18). Incidence rates of heart failure was 2.44 (95%CI 2.31-2.57) vs 0.89 (95%CI 0.87-0.91) in cases vs controls, hazard ratio 3.32 (95%CI 3.13-3.52). Conclusions Individuals with aortic aneurysms had greater prevalence and 3-fold increased risk of developing dilated cardiomyopathy or heart failure, compared to controls. Whether early neurohumeral blockade may delay or prevent the onset of heart failure warrants further investigations.
Christiansen et al. (Sat,) conducted a cohort in Aortic aneurysms (n=164,021). Aortic aneurysms vs. Age- and sex-matched controls was evaluated on Incident dilated cardiomyopathy (HR 3.04, 95% CI 1.50-6.18). Aortic aneurysms were associated with a 3-fold increased risk of incident dilated cardiomyopathy (HR 3.04; 95% CI 1.50-6.18) and heart failure (HR 3.32; 95% CI 3.13-3.52) compared to matched controls.