What question did this study set out to answer?

The aim is to explore how Eupalinolide B impacts PSMD14 and affects oncoprotein levels in acute promyelocytic leukemia cells.

February 6, 2026RSC Chemical Biology0 citationsOpen Access

Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells

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ZCZheng ChuChinese Academy of Medical Sciences & Peking Union Medical College LXLiting XuChinese Academy of Medical Sciences & Peking Union Medical College HCHonglin ChenXihua University

Puntos clave

The aim is to explore how Eupalinolide B impacts PSMD14 and affects oncoprotein levels in acute promyelocytic leukemia cells.
Utilized Eupalinolide B to target PSMD14 covalently
Assessed deubiquitinase activity
Measured levels of oncoproteins AKT1 and CDK4
Evaluated cell cycle progression and apoptosis rates
PSMD14 was successfully inactivated by Eupalinolide B
AKT1 and CDK4 levels decreased significantly
Cell cycle arrest occurred following treatment
Apoptosis was induced in leukemia cells as a result of cascaded effects

Resumen

Eupalinolide B covalently targets PSMD14, inhibiting its deubiquitinase activity. This leads to degradation of oncoproteins AKT1 and CDK4, resulting in cell cycle arrest and apoptosis in leukemia cells.

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Covalent targeting of PSMD14 by Eupalinolide B induces oncoprotein degradation and apoptosis in acute promyelocytic leukemia cells

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