Abstract Recent research has demonstrated a novel copper-catalyzed method for formal aldehydic C–H borylation utilizing a new sp2–sp3 diboron reagent, LBH2-Bpin. This approach provides a streamlined route to a wide range of acylboranes, which are valuable intermediates in medicinal chemistry. This Synpact article reviews the traditional synthetic methods of acylboranes and the uniqueness of this aldehydic C–H borylation protocol.
Lin et al. (Thu,) studied this question.