Each one-unit increase in TyG index raised CAD risk by 69.5% in men and 89.2% in women; TyG and TyG-WHtR also predicted brain ischemia risk in men but not women.
Do the TyG index and TyG-obesity-related parameters predict the incidence of cardiovascular disease in adults?
The TyG index and TyG-WHtR are reliable predictors of coronary artery disease and brain ischemia in men, whereas the TyG index is the most effective predictor of coronary artery disease in women.
Tasa de eventos absoluta: 0% vs 0%
Abstract Introduction The triglyceride glucose (TyG) index and TyG-obesity related indicators have been proposed as a marker of insulin resistance. It is unclear which one is the best indicator to predict cardiovascular diseases. Purpose This study aimed to investigate the predictive value of different biomarkers of TyG for the incidence of cardiovascular disease (CVD) Methods This 10-year prospective cohort study initially enrolled 9,704 individuals aged 35-65 years, with 7,560 participants completing the study. During the follow-up period, 757 cases of coronary artery disease (CAD) and 118 cases of brain ischemia were confirmed. Additionally, 146 patients succumbed to CAD and 39 to brain ischemia. Anthropometric features and indices were measured and calculated using standardized methods. Serum lipid profiles and fasting blood glucose were also measured by standard techniques. Various TyG-related indices, including waist-to-height ratio (WHtR), TyG-BMI, TyG-Waist, and TyG-WHtR, were calculated. Results Out of a total of 757 cases of CAD 45.7% were male and 54.3% were female. Among subjects who experienced brain ischemia 37.3% were male and 62.7% were female.Based on the results of this study, 11.9% of males and 9.3% of females experienced CAD. Additionally,1.5% of males and 1.7% of females had experienced brain ischemia. The incidence of CAD was significantly higher in males than in females, but there were no significant differences between the genders in terms of brain ischemia. According to the cox regression model after adjusting for age, marital status, job, education, smoking, physical activity and energy intake, an increase of one unit in TyG, TyG-BMI, TyG-waist and TyG-WHtR was associated with an increased risk of CAD in males 1.695 (1.426-2.016), 1.425 (1.158-1.755), 1.003 (1.002-1.004) and 1.588 (1.354-1.874), respectively. In females, anincrease of one unit in TyG, TyG-waist and TyG-WHtR was associated with an increased risk of CAD 1.892(1.598-2.240), 1.003 (1.001-1.005) and 1.473 (1.271-1.708), respectively. An increase of one unit in TyG, TyG-BMI, TyG-waist and TyG-WHtR in males was associated with a risk of brain ischemia 2.161 (1.332-3.506), 1.012 (1.003-1.02), 1.004 (1.001-1.007) and 1.991 (1.227-3.231), respectively. However, these factors were not associated with the risk of brain ischemia in females.table 1. Figure 1 Conclusion According to these findings, TyG and TyG-WHtR are reliable predictors of heart disease in men, whereas TyG is the best predictor for women. Furthermore, in men, TyG and TyG-WHtR are also strong indicators of brain events, but none of these markers are effective predictors of brain events in women. In summary, TyG and TyG-WHtR can predict heart disease in men, with TyG being the most effective marker for women. However, while these markers are strong predictors of brain events in men, they lack predictive value for such events in women.figure 1 figure 2
Bikdelu et al. (Sat,) reported a other. Each one-unit increase in TyG index raised CAD risk by 69.5% in men and 89.2% in women; TyG and TyG-WHtR also predicted brain ischemia risk in men but not women.