Early menopause, history of stillbirth, miscarriage, hysterectomy, and bilateral oophorectomy significantly increase mitral regurgitation risk in women.
Do female-specific factors such as early menopause, adverse pregnancy outcomes, or gynecological surgeries increase the risk of mitral regurgitation in women?
Female-specific factors linked to hormonal imbalances, such as early menopause and a history of adverse pregnancy outcomes or gynecological surgeries, are significantly associated with an increased risk of developing mitral regurgitation.
Tasa de eventos absoluta: 0% vs 0%
Abstract Background Female hormones play a protective role in the cardiovascular system by slowing down the calcification process, which in turn reduces cardiovascular risk in women. However, the relationship between female-specific factors and the development of valvular heart disease remains insufficiently explored. Purpose Our aim was to investigate whether sex-specific factors influence the incidence of mitral regurgitation in females. Methods Data for this study was obtained from the UK BioBank Database, a comprehensive population-based cohort comprising 501,726 individuals aged between 40 and 69 years included during the period of 2006-2010. Baseline information, including female specific information was collected through a dedicated questionnaire. Additional information on medical conditions was sourced from electronic hospital inpatient records and primary care records. The primary outcome of interest was the diagnosis of mitral regurgitation, defined by the International Statistical Classification of Diseases and Related Health Problems code I34. To investigate the association between the female factors and mitral regurgitation, logistic regression models were employed. These models were adjusted for other established risk factors of mitral regurgitation, including age, atrial fibrillation, arterial hypertension, heart failure, aortic disease and a history of an acute myocardial infarction. Results A total of 273,193 female participants (mean age 56 ± 8 years) were included in the present analysis. Mitral regurgitation was diagnosed in 3245 (1.2%) females. Significant differences were observed in all prespecified risk factors between patients diagnosed with MR and those without it (all p values 0.001). In the multivariate logistic regression analysis, earlier menopause, history of stillbirth, spontaneous miscarriage or termination, history of hysterectomy and history of bilateral oophorectomy significantly increased the risk of mitral regurgitation in both adjusted models. Conclusion Hormonal imbalances, manifesting as early physiological or surgical menopause and a history of stillbirths or miscarriages, elevate the risk of mitral regurgitation in females. While these factors have been previously recognized for their impact on increased cardiovascular risk in women, this study is the first to directly associate them with an increased risk of mitral regurgitation.Results of logistic regression models.
Bartkowiak et al. (Sat,) reported a other. Early menopause, history of stillbirth, miscarriage, hysterectomy, and bilateral oophorectomy significantly increase mitral regurgitation risk in women.