Higher baseline cognitive function, especially in attention and calculation, is associated with greater exercise capacity improvement during cardiac rehabilitation in CAD patients (β=0.232, p=0.033).
Does baseline cognitive function predict changes in exercise capacity in patients with CAD undergoing cardiac rehabilitation?
Higher baseline cognitive function, particularly in attention and calculation, predicts greater improvements in exercise capacity during cardiac rehabilitation in patients with CAD.
Tasa de eventos absoluta: 0% vs 0%
Abstract Introduction Coronary artery disease (CAD) is a common heart problem associated with poor health-related quality of life 1, significant morbidity and mortality 2, and cognitive decline in affected individuals 3. Cognitive decline may exacerbate the overall burden of the disease 4. Exercise capacity (EC) is known to decline with the progression of CAD, and improvement in EC is considered an important objective marker of successful CAD treatment 5, 6. The role of cognitive function following an acute cardiac event in determining EC changes in this population remains unclear. Purpose The aim of our study was to evaluate the associations between baseline measures of cognitive function and change in EC in patients with CAD undergoing cardiac rehabilitation (CR). Methods This prospective observational cohort study consisted of 100 participants (64.0% men and 36.0% women; mean age 70.87±4.51 years) with CAD after acute coronary syndrome undergoing CR. Baseline characteristics included measures of sociodemographic and clinical factors including age, sex, New York Heart Association (NYHA) functional class, anxiety and depression symptoms as measured by the Generalized Anxiety Disorder Scale-7 and the Patient Health Questionnaire -9. Cognitive functions were assessed using the Mini Mental State Examination (MMSE). EC was evaluated using the 6-minute walk test (6MWT) at baseline and after CR. Multivariable regression model was used to examine the relationships between cognitive function at baseline and change in EC. Univariate models were used to determine if specific MMSE domains are associated with change in EC. Results In a multivariable regression model, adjusted by sociodemographic and clinical factors, the change in EC was associated with baseline scores of global cognitive functions as measured by the MMSE (β=.232, p = .033). Univariate models indicated attention and calculation domain as a specific factor that was associated with change in EC (β=.244, p = .015). Conclusion In patients with CAD undergoing rehabilitation, higher baseline cognitive function, particularly in the attention and calculation domain, is associated with greater improvement in EC during CR.
Garbenytė-Apolinskienė et al. (Sat,) reported a other. Higher baseline cognitive function, especially in attention and calculation, is associated with greater exercise capacity improvement during cardiac rehabilitation in CAD patients (β=0.232, p=0.033).