Clinical obesity increased risk of any arrhythmias by 28% (aHR 1.28) and atrial fibrillation by 34% (aHR 1.34) versus non-obesity over 14.6 years.
Does preclinical and clinical obesity increase the risk of new-onset arrhythmias in individuals without prior arrhythmias?
Both preclinical and clinical obesity, as defined by the novel Lancet framework, are associated with a significantly increased risk of various arrhythmias and proarrhythmic ECG changes over a 14.6-year follow-up.
Tasa de eventos absoluta: 0% vs 0%
Abstract Background Obesity has been associated with increased risk of arrhythmias. However, current BMI-based diagnostic paradigm is unable to capture the complexity of obesity. The Lancet Diabetes 0.001), SVA (aHR 1.09, P0.001), atrial fibrillation (aHR 1.10, P0.001), and cardiac block (aHR 1.08, P0.001) (Figure 1). Compared to non-obesity, clinical obesity significantly increased the risk of any arrhythmias (aHR 1.28, P0.001), SVA (aHR 1.31, P0.001), bradyarrhythmias (aHR 1.24, P0.001), VA (aHR 1.16, P0.001), AF (aHR 1.34, P0.001), cardiac block (aHR 1.28, P0.001), pacemaker insertion (aHR 1.18, P0.001), ventricular tachycardia (aHR 1.22, P0.001), implantable cardioverter defibrillator insertion (aHR 1.44, P0.001), and cardiac arrest (aHR 1.16, P=0.009) (Figure 1). When compared to preclinical obesity, clinical obesity was associated with significantly higher risk of any arrhythmias, SVA, bradyarrhythmias, VA, AF, supraventricular tachycardia, cardiac block, sinus node dysfunction, pacemaker insertion, premature ventricular beats, VT, and cardiac arrest (all p0.05) (Figure 2). Additionally, clinical obesity exhibited significant correlations with ECG alterations, including prolonged P-wave duration, PR interval, QTc interval, and QRS duration, accompanied by shortened RR interval, elevated ventricular rate, significant altered P-wave axis and R-wave axis (all P0.05), compared to preclinical obesity (Figure 2). Conclusions Both preclinical and clinical obesity confer elevated arrhythmia risks, with clinical obesity demonstrating particularly pronounced associations across atrial, ventricular, and conduction system arrhythmias and presenting with significant proarrhythmic electrophysiological shifts.Figure 1 Figure 2
Zhang et al. (Sat,) reported a other. Clinical obesity increased risk of any arrhythmias by 28% (aHR 1.28) and atrial fibrillation by 34% (aHR 1.34) versus non-obesity over 14.6 years.