What question did this study set out to answer?

Evaluate the effectiveness of topical diltiazem in managing pain associated with cutaneous leiomyoma.

February 11, 2026Australasian Journal of Dermatology0 citations

Topical Diltiazem in the Management of Cutaneous Leiomyoma–Associated Pain: Evaluation With a Cold‐Provocation Test

SÖSamet ÖnerDokuz Eylül University CACeylan AvcıDokuz Eylül University AAArzu AvcıIzmir University

Puntos clave

Evaluate the effectiveness of topical diltiazem in managing pain associated with cutaneous leiomyoma.
Case report of a patient with hereditary leiomyomatosis and renal cell cancer.
Topical diltiazem 2% was applied to the affected area.
Pain reduction was assessed using a cold-provocation test.
Pain scores were validated to quantify the change in pain levels.
Topical diltiazem was associated with a significant reduction in pain during the cold-provocation test.
Validated pain scores showed improvement following treatment.

Resumen

ABSTRACT Cutaneous leiomyomas can cause severe pain that may be spontaneous or stimulus‐evoked, and is commonly exacerbated by cold exposure, mechanical pressure/touch, or stress. We report a patient with genetically confirmed hereditary leiomyomatosis and renal cell cancer (HLRCC) in whom topical diltiazem 2% was associated with reduced pain, assessed using a controlled cold‐provocation test and validated pain scores. This brief report suggests that topical diltiazem may be a useful symptomatic option and supports further evaluation.

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