What question did this study set out to answer?

The aim is to analyze the genomic features of K. pneumoniae associated with resistance in an immunocompromised individual.

February 12, 2026Open Access

Genomic Analysis of Coexisting β-Lactamase Plasmids in Klebsiella pneumoniae from an immunocompromised patient

Puntos clave

The aim is to analyze the genomic features of K. pneumoniae associated with resistance in an immunocompromised individual.
Conducted genomic profiling of the K. pneumoniae isolate KP-JZ177.
Identified resistance and virulence determinants on multiple plasmids.
Compared plasmid structures with geographically distant strains.
KP-JZ177 carries significant resistance genes, including bla_OXA-48 and bla_NDM-1.
Plasmid similarities highlight global circulation of antimicrobial resistance.
Emphasizes the importance of monitoring ST147 CRKP isolates in at-risk populations.

Resumen

Genomic profiling of KP-JZ177 reveals high-risk K. pneumoniae clone carrying extensive resistance and virulence determinants on multiple plasmids, including blaOXA-48 and blaNDM-1. Its plasmids similarity to geographically distant strains underscore global AMR circulation, emphasizing the need for enhanced surveillance of ST147 CRKP isolates in high-risk populations.

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