Abstract Objective To assess the possible hepatic and renal health effects of jet fuels used by the U.S. military. Methods A systematic literature review utilizing epidemiologic, animal toxicological, and mechanistic studies was conducted to evaluate hepatic and renal health effects following jet fuel exposure. Results Epidemiologic evidence for renal and hepatic outcomes was indeterminate , primarily due to the limited number and quality of human studies. Animal toxicological studies provided moderate evidence that jet fuel exposure impacts the renal system, while there was slight evidence for hepatic effects. Conclusions Evidence suggests that exposure to jet fuels may cause nephrotoxicity and hepatotoxicity in humans. However, uncertainty remains due to the inconsistent direction of effects, the limited number of studies examining specific health outcomes, and the few published human studies available for review.
Kotulkar et al. (Tue,) studied this question.
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