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Hydrogen-bonding modulation of RNA versus DNA hairpin folding pathways | Synapse

February 12, 2026

Hydrogen-bonding modulation of RNA versus DNA hairpin folding pathways

YKYong-Qi KeBeijing Institute of Technology LTLi-Qing TaoBeijing Institute of Technology

Puntos clave

To explore the role of the ribose 2'-hydroxyl group in RNA folding dynamics in comparison to DNA.
Analyzed RNA and DNA folding pathways
Examined hydrogen bonding interactions
Compared stability and dynamics of hairpin structures
Identified significant differences in folding pathways between RNA and DNA
Ribose 2'-OH group stabilizes RNA tetraloops
Hydrogen bonding plays a critical role in folding dynamics

Resumen

The ribose 2′-hydroxyl (2′-OH) group is a key chemical feature distinguishing RNA from DNA, yet its precise role in RNA tetraloop folding dynamics remains unclear.

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Cite This Study

Ke et al. (Thu,) studied this question.

synapsesocial.com/papers/698d6ebb5be6419ac0d54888 https://doi.org/https://doi.org/10.1039/d5cp04294a

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