Introduction: Insulin resistance (IR) is a central mechanism of sarcopenic obesity and type 2 diabetes mellitus (T2DM). The association of triglyceride-glucose index (TyG index) with central adiposity and skeletal muscle strength in T2DM has been a subject of research. In this study, we assessed the TyG index in relation to waist circumference (WC) and hand grip strength (HGS). We hypothesized that the TyG index should show a positive relation with WC and a negative association with HGS. Materials and Methods: One hundred ambulatory patients with T2DM were enrolled in the study. Their detailed anthropometry, especially the WC and HGS, was recorded. Glycosylated hemoglobin (HbA1c), lipid profile, C-reactive protein (CRP), interleukin-6 (IL6), and fasting plasma insulin were measured. The TyG index was computed from the data. The data were analyzed using the latest version of standard statistical software. Results: In this study of 100 participants (40 males, 60 females; mean age 49.86 years), the majority (93%) were overweight or obese. 80% of males and 95% of females had central adiposity. The mean TyG index was 5.06 ± 0.15. Poor muscle strength (HGS) was observed in 99% of participants. The TyG index showed poor correlation with body mass index (BMI), WC, or HGS. However, it correlated positively with HbA1c, IL6, CRP, and homeostatic model assessment of IR. Conclusions: The mean TyG index for our population was abnormally high. Almost all patients had poor muscle strength. This study comprehensively documents the unique associations of the TyG index with BMI, central adiposity, muscle strength, markers of IR, and inflammation in the North Indian population.
Kak et al. (Thu,) studied this question.
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