Monoclonal gammopathy of renal significance in western China: A large cohort study dominated by amyloidosis with distinct clinical outcomes

Puntos clave

• The aim is to investigate the clinical outcomes of monoclonal gammopathy of renal significance (MGRS) in a large cohort, focusing on amyloidosis cases.
• Examined a large cohort of MGRS patients in Western China.
• Categorized patients based on amyloidosis and non-amyloidosis (MGRS-A and MGRS-NA).
• Analyzed therapeutic responses and their impact on both hematologic and renal outcomes.
• Amyloidosis was identified as the main cause of kidney injury in MGRS cases.
• Patients with MGRS-A had a worse prognosis compared to those with MGRS-NA.
• Key prognostic markers included age and cardiac involvement, influencing renal and patient survival.