What question did this study set out to answer?

This research aims to assess the effectiveness of non-invasive pulsed ultrasound in enhancing hematoma clearance and neurological recovery after intracerebral hemorrhage.

February 14, 2026Open Access

Non-invasive pulsed ultrasound enhances hematoma clearance and neurological recovery in experimental intracerebral hemorrhage

Puntos clave

This research aims to assess the effectiveness of non-invasive pulsed ultrasound in enhancing hematoma clearance and neurological recovery after intracerebral hemorrhage.
Conducted on 29 rats with induced intracerebral hemorrhage using autologous blood.
Rats were divided into control and two ultrasound treatment groups (2 MHz and 8 MHz).
Ultrasound treatment was applied for 60 minutes daily over 7 days post-ICH induction.
Hematoma volume and edema were evaluated using T2-weighted and susceptibility-weighted imaging.
Neurological function was assessed using behavioral tests at multiple time points.
Non-invasive ultrasound significantly enhanced hematoma clearance (47.7% for 2 MHz and 47.8% for 8 MHz compared to 20.4% in control), p < 0.01.
PHE resolution was significantly better in ultrasound groups (53.9% for 2 MHz, 71.8% for 8 MHz, compared to 31.1% in control), p < 0.05.
Behavioral tests showed improvements in right-turn bias and forelimb use in ultrasound-treated groups, p < 0.05.
No significant differences were observed between the two ultrasound frequencies.

Resumen

Background Intracerebral Hemorrhage (ICH) is a devastating stroke subtype. Accelerating hematoma clearance is a critical therapeutic goal. This study evaluated non-invasive pulsed ultrasound for enhancing hematoma clearance, edema resolution, and recovery post-ICH. Methods Twenty-nine rats with striatal autologous blood-induced ICH were randomized into control ( n = 11), 2 MHz ultrasound ( n = 7), and 8 MHz ultrasound ( n = 11) groups. Ultrasound treatment (60 min/day) was applied for 7 consecutive days following ICH induction. Hematoma volume and perihematomal edema (PHE) were assessed by T2-weighted imaging (T2WI) and susceptibility-weighted imaging (SWI) at days 1 and 7 post-ICH. Neurological function was assessed by corner turn and cylinder tests at baseline and days 1, 3, and 7. Results Non-invasive pulsed ultrasound significantly enhanced hematoma clearance (2 MHz: 47.7%; 8 MHz: 47.8% vs. control: 20.4%, p 0.01) and PHE resolution (2 MHz: 53.9%; 8 MHz: 71.8% vs. control: 31.1%, p 0.05). Behavioral tests showed reduced right-turn bias and forelimb asymmetry in ultrasound groups ( p 0.05). No frequency difference was found. Conclusion Non-invasive pulsed ultrasound significantly enhances hematoma clearance, reduces edema, and improves functional recovery post-ICH, supporting its translational potential.

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