Dual inhibition of ERα/NF-κB pathways coupled with sonodynamic therapy via a multifunctional AIEgen
Puntos clave
The research aims to explore the effects of a trifunctional sonosensitizer on ERα and NF-κB pathways for cancer therapy.
Developed TBEP, a multifunctional sonosensitizer with AIE properties.
Utilized ultrasound to trigger reactive oxygen species (ROS) generation.
Targeted ERα using estradiol and anti-inflammatory effects via pterostilbene.
TBEP effectively generated ROS upon ultrasound exposure.
Demonstrated significant inhibition of ERα and NF-κB pathways.
Showed potential for reducing inflammation in cancer treatment.
Resumen
Here we report TBEP, a trifunctional sonosensitizer integrating AIE characteristics for ultrasound-triggered ROS generation, estradiol-mediated ERα targeting, and pterostilbene-derived anti-inflamation.
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Dual inhibition of ERα/NF-κB pathways coupled with sonodynamic therapy via a multifunctional AIEgen | Synapse