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Extramedullary hematopoiesis in the spleen contributes to natural killer cell development during infection and inflammation | Synapse
February 14, 2026
Open Access
Extramedullary hematopoiesis in the spleen contributes to natural killer cell development during infection and inflammation
TB
Tanja Bulat
SM
Sara Miranda
JJ
Jelena Josipović
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Puntos clave
Investigate the role of extramedullary hematopoiesis in the spleen in developing natural killer cells during infection and inflammation.
Analyze spleen samples in infected and inflamed models
Examine cellular development pathways
Evaluate NK cell population changes
Increased NK cell development observed in the spleen during infection
Extramedullary hematopoiesis significantly contributes to NK cell maturation
The process is vital for effective immune response
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Cite This Study
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Bulat et al. (Thu,) studied this question.
synapsesocial.com/papers/699011522ccff479cfe57ea6
https://doi.org/https://doi.org/10.3324/haematol.2025.289028