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Expression of the Necroptosis-Related Gene MLKL Correlated with Small Cell Lung Cancer Prognosis and the Immune Checkpoint | Synapse
February 16, 2026
Open Access
Expression of the Necroptosis-Related Gene MLKL Correlated with Small Cell Lung Cancer Prognosis and the Immune Checkpoint
YH
Yujia Hao
GS
Guangqian Si
YG
Ying Guo
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Puntos clave
This research aims to investigate the correlation between MLKL gene expression and prognosis in small cell lung cancer (SCLC).
Analyzed expression levels of MLKL in SCLC tissue samples
Examined correlations with patient prognosis and immune checkpoint markers
Utilized statistical methods to assess significance of findings.
Higher MLKL expression correlated with worse prognosis in SCLC patients
Presence of immune checkpoint markers associated with MLKL levels
Findings suggest a potential role for MLKL in therapeutic strategies for SCLC.
Resumen
Necroptosis, SCLC, Prognosis, Immune checkpoint.
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Hao et al. (Sun,) studied this question.
synapsesocial.com/papers/69926552eb1f82dc367a1246
https://doi.org/https://doi.org/10.29271/jcpsp.2026.02.186