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The impact of CNV burden on age at onset of schizophrenia | Synapse

February 17, 2026Open Access

The impact of CNV burden on age at onset of schizophrenia

Puntos clave

To investigate how CNV deletions affect the age at onset of schizophrenia.
Analyzed the relationship between CNV burden and age at onset of schizophrenia.
Utilized genetic tests to identify CNVs in study participants.
Examined neurodevelopmental pathways influenced by CNVs.
Increased CNV deletions correlate with earlier onset of schizophrenia.
Findings underscore the role of genetic factors in schizophrenia development.

Resumen

These findings suggest that an increased burden of CNV deletions may disrupt neurodevelopmental pathways, contributing to earlier onset of SCZ. This study highlights the importance of CNV burden in elucidating the genetic architecture underlying SCZ and AAO, and emphasizes the value of using genetic tests to detect CNVs in informing future therapeutic approaches.

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Cite This Study

Muntané et al. (Fri,) studied this question.

synapsesocial.com/papers/699405254e9c9e835dfd5ed3 https://doi.org/https://doi.org/10.1016/j.schres.2026.02.006