What question did this study set out to answer?

The research investigates how predator stress affects seizure susceptibility and underlying neurotransmitter pathways.

February 17, 2026Open Access

The impact of predator stress on electroshock seizure threshold: insights into GABAergic, glutamatergic, and serotonergic pathways in mice

Puntos clave

The research investigates how predator stress affects seizure susceptibility and underlying neurotransmitter pathways.
Examined seizure threshold in mice under predator stress.
Analyzed hippocampal expression of GABAAα1R and 5-HT1AR.
Monitored NF-κB activation and ERK signaling levels.
Applied pharmacological modulation to neurotransmitter pathways.
Predator stress increased susceptibility to seizures.
Downregulation of hippocampal GABAAα1R and 5-HT1AR was observed.
Enhanced NF-κB activation and reduced ERK signaling were identified.
Pharmacological interventions reversed the stress-induced decrease in seizure threshold.

Resumen

This study shows that predator stress is associated with increased seizure susceptibility and with downregulation of hippocampal GABAAα1R and 5-HT1AR expression, together with enhanced NF-κB activation and reduced ERK signaling. Pharmacological modulation of GABAergic, glutamatergic, and serotonergic pathways reversed the stress-induced reduction in seizure threshold in this model, suggesting that these systems may contribute to stress-related seizure susceptibility.

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