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February 19, 2026

Evaluation of Remodeling and Regeneration of Electrospun PLGA@PCL/Elastin Small-Diameter Vascular Grafts In Vivo

Puntos clave

The aim is to assess the remodeling and regeneration of electrospun PLGA@PCL/elastin vascular grafts in vivo.
Preparation of PLGA@PCL/elastin core/shell small-diameter vascular grafts via electrospinning.
Investigation of cross-linking effects using EDCI and NHS reagents.
Conducting in vivo transplantation in the abdominal aorta to assess graft performance.
PCEs SDVGs cross-linked with EDC/NHS maintained high soluble elastin content.
Achieved compliance of 1.74 ± 0.62%/mmHg × 10^-2 and bursting pressure of 1750 mmHg.
In vivo grafts remained patent without aneurysm formation and promoted neointimal tissue formation while suppressing calcification.

Resumen

Bypass vascular grafting is an effective treatment for cardiovascular disease. Currently, small-diameter vascular grafts (SDVGs, inner diameter N-hydroxysuccinimide (NHS) retained the most soluble elastin content and achieved a compliance of 1.74 ± 0.62%/mmHg × 10-2, a bursting pressure of 1750 mmHg, and a tensile strength of 2.09 ± 0.51 MPa, which are mostly close to those of human saphenous vein. Subsequently, in vivo transplantation in the abdominal aorta showed that all implanted SDVGs cross-linked by EDC/NHS (PCEsEN) remained patent without aneurysm formation. Histological staining results further showed that the introduction of elastin not only promoted the degradation of SDVGs but also accelerated the formation of neointimal tissue and suppressed the calcification. Thus, PCEsEN shows promising potential to be translated into SDVGs in clinic.

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Cite This Study

Xiao et al. (Mon,) studied this question.

synapsesocial.com/papers/6996a869ecb39a600b3ef29d https://doi.org/https://doi.org/10.1021/acsabm.5c01637

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