What does this research mean for the field?

Vestibulo-ocular reflex (VOR) integrity is associated with cognitive and gait function in patients with de novo Parkinson's disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research examines the relationship between vestibulo-ocular reflex (VOR) and cognitive functions in newly diagnosed Parkinson's disease patients.

February 25, 2026Open Access

Association between vestibulo-ocular reflex and cognitive function in de novo Parkinson’s disease

Puntos clave

This research examines the relationship between vestibulo-ocular reflex (VOR) and cognitive functions in newly diagnosed Parkinson's disease patients.
Evaluated VOR gain in multiple canals using Video Head Impulse Tests (Video-HITs).
Conducted cognitive assessments using the Montreal Cognitive Assessment.
Analyzed correlations between VOR gains and neuropsychological measures across different cognitive domains.
Decreased VOR gain was noted in 17.3% of patients.
Positive correlation found between horizontal canal gain and cognitive assessment scores (p=0.040).
Canal-specific relationships indicated that horizontal canal gain related positively to visuospatial function, while others negatively affected language and executive functions.

Resumen

Decreased VOR gain in at least one canal was observed in 22 patients (17.3%). Horizontal canal (HC) gain was positively associated with the Montreal Cognitive Assessment (p=0.040), anterior canal (AC) gain had negative association with the base of support (p=0.018). Patterns of association between VOR gains and neuropsychological measures differed between PD-NC and PD-MCI. In addition, VOR-cognition relationships were canal-specific: HC gain was positively related to visuospatial function, whereas AC and posterior canal gains were negatively related to language and frontal-executive functions. DAT uptake in the locus coeruleus was positively correlated with HC gain (p=0.020). Conclusion: VOR integrity is associated with cognitive and gait function in patients with PD. Video-HITs may serve as a potential biomarker for disease monitoring in PD.

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