Human expansion into deep space necessitates sustainable life support. Current prepackaged food systems face nutritional, logistical, and psychological limits on long missions. Cell agriculture, particularly yeast-based biomanufacturing, emerges as a pivotal solution. Yeast's genetic flexibility, metabolic resilience, and tolerance to extreme conditions make it an ideal chassis for in-situ food and nutrient production. This review systematically explores yeast's application in creating closed-loop space food systems, analyzing its progress, challenges, and future potential for enabling sustained extraterrestrial presence.
Yin et al. (Mon,) studied this question.