Exploring the anti-diabetic potential of bis-Schiff bases of ibuprofen: insights into the in vitro , molecular docking and density functional theory analyses | Synapse
February 26, 2026Open Access
Exploring the anti-diabetic potential of bis-Schiff bases of ibuprofen: insights into the in vitro , molecular docking and density functional theory analyses
Puntos clave
This research aims to evaluate the anti-diabetic potential of bis-Schiff base derivatives of ibuprofen.
In vitro evaluation against α-amylase and α-glucosidase enzymes.
Molecular docking analysis to predict binding interactions.
Density functional theory analysis to examine electronic properties.
Bis-Schiff bases exhibited significant inhibition of α-amylase and α-glucosidase.
Molecular docking indicated favorable interactions with target enzymes.
Density functional theory highlighted strong electron donation capabilities.
Resumen
Evaluation of bis-Schiff base derivatives of ibuprofen against α-amylase and α-glucosidase, their molecular docking and density functional theory analysis.