What question did this study set out to answer?

The research aims to investigate how Notopterol affects atherosclerosis and cholesterol metabolism in macrophages.

February 28, 2026Open Access

Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction

Puntos clave

The research aims to investigate how Notopterol affects atherosclerosis and cholesterol metabolism in macrophages.
Examined atherosclerotic plaque in apoE-/- mice treated with Notopterol.
Measured lipid accumulation and lesion area to assess atherosclerosis.
Analyzed cholesterol efflux in macrophages and expression of specific transporters.
Studied the interaction between Keap1 and Nrf2 pathways.
Notopterol significantly reduced atherosclerotic plaque and improved plasma lipids.
Notopterol enhanced cholesterol efflux in macrophages by increasing ABCA1 and ABCG1 expression.
Activation of the Nrf2-HO-1 pathway was linked to Notopterol's protective effects against atherosclerosis.
Notopterol disrupted the Keap1-Nrf2 complex, promoting Nrf2 pathway activation.

Resumen

• NOT reduces atherosclerotic plaque in apoE - / - mice: decreases lipid accumulation and lesion area, improves plasma lipids. • NOT enhances cholesterol efflux in macrophages: boosts ABCA1/G1 expression and efflux, reducing cholesterol in foam cells. • Nrf2-HO-1 pathway mediates NOT effects: involved in ABCA1/G1 expression and atherosclerosis protection. • NOT disrupts Keap1-Nrf2 complex: binds Keap1, inhibits complex formation, activating Nrf2-HO-1 pathway. • Study offers new insights: NOT's atherosclerotic protection suggests therapeutic potential for prevention.

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Authors

Yusheng Qin

Liuzhou Maternal and Child Health Hospital

Jun Meng

Xinjiang Agricultural University

Yanjun Chen

Journals

International Immunopharmacology

Actions

Institutions

Army Medical University

Southwest Hospital

University of South China

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Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction

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Resumen

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Discussion

Authors

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References and Citations

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