Asymmetric Hydrogenation of N -Heterocycles for Pharmaceutical Intermediates: Synthetic Strategies and Theoretical Perspectives

Puntos clave

• The aim is to investigate the role of asymmetric hydrogenation in synthesizing chiral nitrogen-containing heterocycles for drug development.
• Reviewed synthetic strategies for asymmetric hydrogenation of heterocycles.
• Analyzed the theoretical perspectives on chiral compound formation.
• Discussed the implications for pharmaceutical applications.
• Chiral nitrogen-containing heterocycles enhance drug targeting and minimize toxicity.
• Asymmetric hydrogenation presents efficient pathways for producing these intermediates.
• The increasing approval of small-molecule drugs highlights their importance in modern medicine.