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Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH | Synapse

February 28, 2026

Myeloid KIF13B suppresses the STT3A/CTSD/THBS1 Axis to prevent MASH

Puntos clave

The research aims to define the regulatory mechanisms involved in macrophage-hepatocyte interactions during MASLD.
Identified the ZNF384/KIF13B/STT3A/CTSD/THBS1 axis in macrophages and hepatocytes.
Examined the role of KIF13B in the regulation of this axis.
Investigated the implications for MASLD progression.
Establishment of a new regulatory pathway essential for MASLD.
KIF13B suppression linked to dysregulation of the STT3A/CTSD/THBS1 axis.
Potential therapeutic targets were identified for MASLD management.

Resumen

Collectively, our study establishes a novel regulatory axis, ZNF384/KIF13B/STT3A/CTSD/THBS1, essential for macrophage-hepatocyte crosstalk during MASLD progression and providing potential therapeutic targets for the treatment of MASLD.

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Cite This Study

Lu et al. (Wed,) studied this question.

synapsesocial.com/papers/69a286950a974eb0d3c01a23 https://doi.org/https://doi.org/10.1097/hep.0000000000001726

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