The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin | Synapse
February 28, 2026RSC Medicinal Chemistry0 citations
The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin
The research focuses on the dual roles of SF-4 in combating influenza A virus and inflammation by targeting specific signaling pathways.
In vitro experiments to assess the effect of SF-4 on viral infection.
Evaluation of NF-κB pathway inhibition.
Analysis of Nrf2/HO-1 pathway activation.
SF-4 significantly inhibits influenza A virus infection.
SF-4 reduces the excessive inflammatory response by blocking NF-κB activation.
Activation of the Nrf2/HO-1 pathway correlates with the anti-inflammatory effects observed.
Resumen
SF-4 inhibits influenza virus infection and the excessive inflammatory response resulting from viral infection by inhibiting NF-κB activation and activating the Nrf2/HO-1 pathway.