Metabolic and renal predictors of coronary artery calcification: the independent role of the uric acid/estimated glomerular filtration rate (UA/eGFR) ratio and Castelli indices

pstrongABSTRACT/strong/p pstrongAim /strongTo examine the association between metabolic parameters and novel cardiometabolic indices with the coronary artery calcium score (CACS)./p pstrongMethods: /strongThis retrospective cross-sectional study included 130 patients who underwent coronary computed tomography angiography (CCTA) at the Radiology Clinic of the Clinical Centre of the University of Sarajevo between January and June 2024.strong /strongPatients were classified into two groups: those with CACS le;100 and those with CACS gt;100.strong /strongPlatelet count, mean platelet volume (MPV), estimated glomerular filtration rate (eGFR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), uric acid (UA), and novel cardiometabolic indices, including Castelli risk index I and II (CRI-I and CRI-II), non-high-density lipoprotein cholesterol (non-HDL-C), were compared between the groups./p pstrongResults /strongPatients with CACS gt;100 had significantly higher MPV, TC, LDL-C, UA, non-HDL-C, CRI-I, CRI-II, and the UA/eGFR ratio. Older age, increased platelet activity, dyslipidemia, hyperuricemia, and the higher UA/eGFR ratio correlated positively with CACS, whereas eGFR correlated negatively. In multivariate regression analysis, the UA/eGFR ratio emerged as an independent predictor of higher CACS (OR = 2.37; 95% CI 1.18ndash;4.78; p=0.017)./p pstrongConclusion /strongElevated UA levels and adverse cardiometabolic indices are associated with greater coronary artery calcification. The UA/eGFR ratio independently predicts higher CACS, highlighting its potential prognostic value./p pstrongKeywords: /strongcoronary angiography, glomerular filtration rate, uric acid, vascular calcification/p