This study intended to explore behavioral and emotional problems and quality of life, as well as their related factors in Chinese children with Langerhans cell histiocytosis (LCH). This was a cross-sectional study. Subjects were included from April 2023 to September 2023. Child behavior checklist (CBCL), pediatric quality of life inventory™ version 4.0 (PedsQLTM4.0), and version 3.0 (PedsQLTM3.0) Cancer Module were used to assess behavioral and emotional problems and quality of life. A total of 120 children with LCH were included. Twenty-six (21.7%) children had behavioral and emotional problems. Age at diagnosis ≥ 4 years odds ratio (OR) = 0.344, P = 0.022 and major caregiver with an educational level of junior college and above (OR = 0.314, P = 0.035) were independently associated with a lower possibility of achieving CBCL total problem score ≥ 35. Electronic product usage time ≥ 2 h per day (B=-6.024, P = 0.011) and caesarean section (B=-6.006, P = 0.012) were independently related to a lower total PedsQLTM4.0 score, while age at diagnosis ≥ 4 years (B = 9.183, P = 0.004) showed an inverse trend. Second-line treatment was independently related to a lower total PedsQLTM3.0 Cancer Module score (B=-5.578, P = 0.021). In this study, 21.7% of Chinese children with LCH exhibit behavioral and emotional problems. Age at diagnosis < 4 years, major caregiver with an educational level of high school and below, electronic product usage time ≥ 2 h, caesarean section, and second-line treatment are related to behavioral and emotional problems and impaired quality of life in Chinese children with LCH. Not applicable.
Li et al. (Fri,) studied this question.